A Clinico-Microbiological Study of Blood Stream Infections in a Tertiary Referral Hospital: Colistin Resistance & Challenges

Carbapenems, frequently used for the treatment of infections caused by Multidrug-resistant (MDR) Gram-negative bacteria (GNB) are being reported with increased resistance rate. Colistin other antibiotics has emerged as a saviour but inappropriate reporting colistin susceptibility is serious clinical concern. To detect antimicrobial GNB isolates obtained from blood samples, further, Minimum Inhibitory Concentration (MIC) testing carbapenem-resistant was done Broth Micro-dilution Method (BMD). This prospective study in Department Microbiology January 2020 to December 2020. The isolated samples were identified & antimicrobial-susceptibility performed Vitek 2 system. MIC BMD method. data statistically analysed using SPSS 21. Growth 5% and 546 (75.8%) these including predominantly E.coli, Klebsiella spp Acinetobacter spp. Carbapenem-resistant 246 (48.5%) showed significant association ICU admission, classes mortality. Among isolates, only seven (2.9%) found resistant test. Most (71.4%) patients (85.7%). All intermediate sensitive VITEK-2 characterized MDR 323 (59.2%), XDR 164 (30%) PDR (0.4%). Use of, colistin, should be guided BMD, reference method avoid erroneous resistance.